Open Positions

Postdoctoral Positions

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RUPA SRIDHARAN LAB: posted on May 27th, 2022

Requirements: The ideal candidate will be in the last phase of their Ph.D. or a recent graduate in any field of biology with expertise in molecular biology, and at least one first-authored research publication from their thesis work. The Sridharan lab is broadly interested in the mechanism of epigenetic control of cell identity using cutting-edge single-cell genomics, gene editing, and proteomic techniques.

Job Duties: To study the mechanism of histone demethylases control of cell identity in germ cell and neural development from mouse and human embryonic stem cells and in vivo. Projects range from biochemical investigation of the cross-talk between histone and DNA demethylation to single-cell genomic analysis of post-implantation mouse development.

For inquiries or to apply for the position, contact rsridharan2@wisc.edu with CV.

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AUDREY GASCH LAB:  MODEL-ORGANISM GENOMICS TO HUMAN GENETICS – posted on May 9th, 2022

We have open an exciting, funded post-doctoral position that bridges the analysis of model-organism functional genomics data, evolutionary biology, and human genetics and genomics.  As part of a broader collaboration within the UW-Madison Center for Genomic Science Innovation and the NHGRI “Impact of Genomic Variation on Function” (IGVF) consortium, we are developing new methods to i) predict causal variants in human patients with polygenic disorders while ii) understanding the biology of those diseases and iii) how genetic modifiers elsewhere in the genome influence phenotypic expression.

Find out more:  https://gasch.genetics.wisc.edu/human-genetics/

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ALAN ATTIE LAB:  GENETICS & GENOMICS OF DIABETES – posted on May 9th, 2022

We are searching for a post-doctoral scholar to study genes that play a role in diabetes susceptibility. Our discovery platforms are forward genetic and chemical screens in mice and cell lines, exploration of chromatin structure, and deletions of non-coding regulatory DNA containing variants associated with diabetes in human populations. Most of these genes and non-coding variants affect the function of pancreatic beta-cells, the cells that secrete insulin in response to glucose and other nutrients.

We have a broad skill set, which includes physiological experiments in mice, cell biology studies in cell lines, functional and fluorescent imaging studies in pancreatic islets, studies of genomic architecture using ATAC-seq, gene expression studies, and bioinformatic approaches to discover gene expression modules. In addition, we are deeply immersed in complex trait genetics through quantitative trait locus (QTL) mapping and positional cloning.

Our laboratory has a long history of nurturing scholars aspiring to careers in research, teaching, and industry. Post-doctoral and pre-doctoral scholars in the lab benefit from the several technicians who have been in the lab for many years and enjoy training and assisting our scholars. Post-docs gain experience with manuscript and grant writing and are assisted to develop and refine their oral communication skills. In addition, Alan Attie enjoys mentoring scholars in non-traditional approaches to teaching, a great way to develop a ‘teaching portfolio’, a valuable asset when competing for university positions.

Our lab has a rich web of collaborations across the world. Our trainees are an integral part of these collaborations and develop a sense of belonging to this international community.

To inquire about this position, please write to: Alan Attie adattie@wisc.edu

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Staff Positions

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DONNA WERLING LAB:  RESEARCH SPECIALIST

The Werling Lab in UW-Madison’s Department of Genetics is seeking applicants for a Research Specialist position to contribute essential experimental and organizational skills to ongoing research projects on brain development and risk factors for neuropsychiatric disorders.  This work will involve colony management and handling of laboratory mice, as well as laboratory techniques such as PCR, extraction of DNA/RNA/protein from tissue, and a sample prep for high throughput genomic sequencing experiments.  While training will be provided for these techniques, preference will be given to candidates with prior experience with these methods.  Eligible applicants are encouraged to APPLY.  Come join our team!

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CENTER FOR HUMAN GENOMICS & PRECISION MEDICINE:  RESEARCH SERVICE SCIENTIST

The Center for Human Genomics and Precision Medicine (CHGPM) at the School of Medicine and Public Health, focuses its research and clinical activities in applied genomics and personalized medicine which encompasses basic, translational, and clinical research. CHGPM is setting up a new Precision Medicine Research Service, to develop widely utilized laboratory and computational pipelines for human genomics and precision medicine researchers within the School of Medicine and Public Health. To help initiate, manage, and run this service, we are looking for a Research Service Scientist. The incumbent will develop laboratory genomics workflows, utilizing resources available within CHGPM and through our partnership with the Biotechnology Center (for example, custom amplicon sequencing for recurrent genetic polymorphisms and mutations). They will interact closely with faculty and staff within SMPH interested in using such services, and facilitate, execute, and manage client projects. They will further partner with a Bioinformatics Scientist to develop and implement computational pipelines to aid data analysis and interpretation. The position closes May 15, 2022, https://jobs.hr.wisc.edu/en-us/job/513310/research-service-scientist

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CENTER FOR HUMAN GENOMICS & PRECISION MEDICINE: BIOINFORMATICS SCIENTIST

The Center for Human Genomics and Precision Medicine (CHGPM) at the School of Medicine and Public Health, focuses its research and clinical activities in applied genomics and personalized medicine which encompasses basic, translational, and clinical research. CHGPM is setting up a new Precision Medicine Research Service, to develop widely utilized laboratory and computational pipelines for human genomics and precision medicine researchers within the School of Medicine and Public Health. To help address the bioinformatics needs related to this service, we are looking for a Bioinformatics Scientist. The incumbent will develop, adapt, and implement computational and bioinformatics pipelines, utilizing resources available within CHGPM and through our partnership with the SMPH and Biotechnology Center (for example, variant calling and reporting from custom amplicon sequencing for recurrent genetic polymorphisms and mutations). They will interact closely with faculty and staff within SMPH interested in using such services, and facilitate, execute, and manage client projects. They will further partner with a Research Service Scientist to ensure timely execution of projects and delivery of results. The position closes May 15, 2022, https://jobs.hr.wisc.edu/en-us/job/513309/bioinformatics-scientist

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AUDREY GASCH LAB:  RESEARCH TECHNICIAN

We seek an ambitious and highly motivated research specialist to support research activities in the Gasch Lab.  Work will support research studying regulatory networks and environmental responses in fungi as a model for basic biology and disease studies.  The successful candidate will participate in research support on specific projects, including but not limited to yeast strain construction, cloning, yeast tetrad dissection, strain phenotyping, and more.  The candidate will also participate in general lab maintenance as required.  Salary range:  $37,000 to $75,000 depending on qualifications.  We support diversity & are dedicated to creating an inclusive and exciting research environment.  Contact Audrey Gasch (agasch@wisc.edu) for more information & details on how to apply.

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ALAN ATTIE LAB:  SOFTWARE ENGINEER / DEVELOPER II

The Attie Laboratory within the Biochemistry Department at the University of Wisconsin-Madison is seeking qualified candidates for a full-time position for a Bioinformatics Software Engineer.

Our laboratory performs large-scale genetic screens in mice to understand the relationship between genetic diversity and metabolic disease risk. We have a tight-knit team of career technicians and a Senior Scientist to lead this effort, which involves thousands of mice and hundreds of thousands of physiological and molecular measurements. Compiling the “big data” that derives from these studies, and integration with many orthogonal data repositories (e.g., human genetic studies) requires a high-level bioinformatics skills.

In addition to our ongoing mouse genetic studies, we are embarking on an ambitious project to revitalize the discovery potential of tens of thousands of high-quality transcriptomic, proteomic, and other data sets housed within the Gene Expression Omnibus (GEO), as well as unpublished data sets from our collaborators. The typical research experimentalist is not well versed in the bioinformatic skills necessary to identify, curate and analyze individual data sets from these repositories. We aim to construct a user-friendly web interface that will render thousands of these high-volume data sets, resulting in a sophisticated search engine and hypothesis generating tool for a typical research experimentalist.

The successful candidate will work closely with our team and that of our collaborator (Avi Ma’ayan, Mt Sinai School of Medicine) to compile, curate, and construct integrated data platforms for both the ongoing genetic studies, as well as the project to revitalize the potential of GEO data sets. Candidates are required to have a B.S. or M.S. degree in a computer science or related discipline. Programming skills in several platforms (Python, JavaScript, R, C/C++) and experience developing web-based applications (React, NodeJS, RShiny, Flask).

Strong communication skills (verbal and written) are required. The successful candidate will be interacting with groups across the world that have produced high-quality, high-volume datasets that we will be integrating into our Data Hub.  Salary:  $46,000-$85,000 depending on qualifications.

To apply, please contact: Alan Attie