Open Positions

Postdoctoral Positions

HASAN KHATIB LAB: posted on January 25, 2023

Job Title: Post-Doctoral Fellow in Animal Genetics

Job Description: We are seeking a highly motivated post-doctoral fellow to join our research team. The successful candidate will have a Ph.D. in Animal Sciences, Genetics, Reproduction, or related fields and a strong background in bioinformatics.

Responsibilities:

  • Conduct research in nutritional epigenetics in sheep, with a focus on developing and applying computational methods to analyze large-scale genomic data. The research is focused on the effects of paternal nutrition on phenotypes and the epigenome of the subsequent generations.
  • Collaborate with other members in the lab and the sheep unit to design and execute experiments.
  • Mentor graduate and undergraduate students in the lab.

For more information about our research, see a recent paper published in PNAS-Nexus: https://doi.org/10.1093/pnasnexus/pgac040

To apply for the position, contact Dr. Hasan Khatib, hkhatib@wisc.edu, with CV.


RUPA SRIDHARAN LAB: posted on May 27th, 2022

Requirements: The ideal candidate will be in the last phase of their Ph.D. or a recent graduate in any field of biology with expertise in molecular biology, and at least one first-authored research publication from their thesis work. The Sridharan lab is broadly interested in the mechanism of epigenetic control of cell identity using cutting-edge single-cell genomics, gene editing, and proteomic techniques.

Job Duties: To study the mechanism of histone demethylases control of cell identity in germ cell and neural development from mouse and human embryonic stem cells and in vivo. Projects range from biochemical investigation of the cross-talk between histone and DNA demethylation to single-cell genomic analysis of post-implantation mouse development.

For inquiries or to apply for the position, contact rsridharan2@wisc.edu with CV.


ALAN ATTIE LAB:  GENETICS & GENOMICS OF DIABETES – posted on May 9th, 2022

We are searching for a post-doctoral scholar to study genes that play a role in diabetes susceptibility. Our discovery platforms are forward genetic and chemical screens in mice and cell lines, exploration of chromatin structure, and deletions of non-coding regulatory DNA containing variants associated with diabetes in human populations. Most of these genes and non-coding variants affect the function of pancreatic beta-cells, the cells that secrete insulin in response to glucose and other nutrients.

We have a broad skill set, which includes physiological experiments in mice, cell biology studies in cell lines, functional and fluorescent imaging studies in pancreatic islets, studies of genomic architecture using ATAC-seq, gene expression studies, and bioinformatic approaches to discover gene expression modules. In addition, we are deeply immersed in complex trait genetics through quantitative trait locus (QTL) mapping and positional cloning.

Our laboratory has a long history of nurturing scholars aspiring to careers in research, teaching, and industry. Post-doctoral and pre-doctoral scholars in the lab benefit from the several technicians who have been in the lab for many years and enjoy training and assisting our scholars. Post-docs gain experience with manuscript and grant writing and are assisted to develop and refine their oral communication skills. In addition, Alan Attie enjoys mentoring scholars in non-traditional approaches to teaching, a great way to develop a ‘teaching portfolio’, a valuable asset when competing for university positions.

Our lab has a rich web of collaborations across the world. Our trainees are an integral part of these collaborations and develop a sense of belonging to this international community.

To inquire about this position, please write to: Alan Attie adattie@wisc.edu

Staff Positions

ALAN ATTIE LAB:  SOFTWARE ENGINEER / DEVELOPER II

The Attie Laboratory within the Biochemistry Department at the University of Wisconsin-Madison is seeking qualified candidates for a full-time position for a Bioinformatics Software Engineer.

Our laboratory performs large-scale genetic screens in mice to understand the relationship between genetic diversity and metabolic disease risk. We have a tight-knit team of career technicians and a Senior Scientist to lead this effort, which involves thousands of mice and hundreds of thousands of physiological and molecular measurements. Compiling the “big data” that derives from these studies, and integration with many orthogonal data repositories (e.g., human genetic studies) requires a high-level bioinformatics skills.

In addition to our ongoing mouse genetic studies, we are embarking on an ambitious project to revitalize the discovery potential of tens of thousands of high-quality transcriptomic, proteomic, and other data sets housed within the Gene Expression Omnibus (GEO), as well as unpublished data sets from our collaborators. The typical research experimentalist is not well versed in the bioinformatic skills necessary to identify, curate and analyze individual data sets from these repositories. We aim to construct a user-friendly web interface that will render thousands of these high-volume data sets, resulting in a sophisticated search engine and hypothesis generating tool for a typical research experimentalist.

The successful candidate will work closely with our team and that of our collaborator (Avi Ma’ayan, Mt Sinai School of Medicine) to compile, curate, and construct integrated data platforms for both the ongoing genetic studies, as well as the project to revitalize the potential of GEO data sets. Candidates are required to have a B.S. or M.S. degree in a computer science or related discipline. Programming skills in several platforms (Python, JavaScript, R, C/C++) and experience developing web-based applications (React, NodeJS, RShiny, Flask).

Strong communication skills (verbal and written) are required. The successful candidate will be interacting with groups across the world that have produced high-quality, high-volume datasets that we will be integrating into our Data Hub.  Salary:  $46,000-$85,000 depending on qualifications.

To apply, please contact: Alan Attie