Integrative Genomics to Understand Complex

Biological Systems

A complete understanding of living creatures and their behaviors cannot come from studying only one aspect of physiology.  Rather, it emerges from integrating knowledge across scales, domains, and dimensions to understand the network of cellular interactions underlying biological systems.  While new methods of measuring physiology emerge at a rapid pace, how to understand that information in the context of living cells remains a major challenge. Researchers in the CGSI work collaboratively to understand cellular systems. 

Audrey P. Gasch

Genetics, Medical Genetics

Elucidating systems-level relationships between genotype-phenotype-environment in eukaryotic stress responses

Chris Todd Hittinger


The Hittinger lab uses yeast carbon metabolism as a model for basic bioenergy, biomedical and evolutionary research

Nicole Perna


Exploring bacterial genome evolution among plant and animal pathogens

Srivatsan Raman


Systems and synthetic biology approach to understanding and designing biology

Michael R. Sussman


Understanding how the plasma membrane functions in all cells

Donna Werling


Characterizing sex-differential risk mechanisms in autism and other neuropsychiatric disorders using functional genomics, human genetics and
bioinformatics approaches